2011 Vol. 17 Nr 4 - TIDNINGEN

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For example, through a process of central sensitization, the firing of dorsal horn nociceptors can change dramatically in the setting of injury (produced by either tissue or nerve damage). Se hela listan på physio-pedia.com Central sensitization refers to an increased responsiveness of nociceptive neurons in the CNS (Loeser & Treede, 2008). A key feature of central sensitization is the development of an increased sensitivity to mechanical pinprick stimuli that spreads beyond the site of injury or inflammation, a phenomenon also referred to as secondary hyperalgesia. central (spinal) neurons, termed central sensitization. Noci-ceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary hyperalgesia. Because central sensitization is considered to reflect plasticity at spinal synapses, the spinal The focus of this study is to examine the analgesic effects of electroacupuncture (EA) on capsaicin-induced secondary hyperalgesia, which represents central sensitization.

Secondary hyperalgesia central sensitization

Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. 2016-05-11 · However, the secondary hyperalgesia to punctate mechanical stimuli, that occurs as a result of central neuronal plasticity of the nociceptive system is mediated by A-fiber nociceptors, not C-fibers [11–14]. Thus, secondary hyperalgesia as a result of central sensitization elicited by BTS may be significantly distinct from HPDT. Secondary hyperalgesia occurs in the areas around the injured site This technique has been shown to induce central sensitization and to increase cortical processing of visual stimuli Central sensitization is a condition of the nervous system that is associated with the development and maintenance of chronic pain. When central sensitization occurs, the nervous system goes through a process called wind-up and gets regulated in a persistent state of high reactivity.

Acute and Chronic Mechanisms of Pain - ResearchGate

For example, through a process of central sensitization, the firing of dorsal horn nociceptors can change dramatically in the setting of injury (produced by either tissue or nerve damage). 2016-05-11 Because secondary hyperalgesia is short-lived, persistent pain after surgery in large part may be primary hyperalgesia, perhaps amplified by central sensitization.

Secondary hyperalgesia central sensitization

Fibromyalgia and chronic widespread pain - GUPEA

Secondary hyperalgesia refers to the sensitization that occurs because of changes in spinal cord processing. For example, through a process of central sensitization, the firing of dorsal horn nociceptors can change dramatically in the setting of injury (produced by either tissue or nerve damage). Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (high-sensitization responders), while others develop small areas (low-sensitization responders). Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (high-sensitization responders), while others develop small areas (low-sensitization responders). Evidence indicates that primary hyperalgesia is caused by increased responsiveness of primary afferent nociceptors (peripheral sensitization), and secondary hyperalgesia is produced by enhanced responses of dorsal horn neurons to a given peripheral input (central sensitization).
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Conclusions When subjects are observed across days, 'central sensitization', measured as the area of secondary hyperalgesia after a first-degree burn, does not seem to be important for clinical pain intensity per se, but may be important for clinical pain variation. Secondary hyperalgesia refers to the sensitization that occurs because of changes in spinal cord processing.

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These CNS changes may be detected by Secondary hyperalgesia is defined as an increase in pain sensitivity when a noxious stimulus is delivered to a region surrounding, but not including, the zone of This represents central sensitization and is responsible for hypersensitivity, Furthermore, pain sensitivity around the wound (secondary hyperalgesia) was also 6 Jul 1999 Nociceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary investigate gender differences in development of secondary hyperalgesia. Cutaneous sia induce sensitization of central pain transmitting neurons33,36 and 25 Apr 2017 The effects of central sensitization extend beyond nociceptive pathways to other sensory modalities.

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Primary hyperalgesiaand secondary hyperalgesia. Secondary hyperalgesia is indicative of central sensitization. Peripheral sensitization is an increased sensitivity to an afferent nerve stimuli.

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Some researchers speculate central sensitization to be the explanatory This phenomenon became known as primary hyperalgesia (Woolf, 2011).

Although av C LINNMAN · 2008 — The second study evaluated central expression of the neurokininY1 (NK1) receptor in WAD patients and pain sensitization and activity dependent neuronal plasticity. ceptors in the RVM contributes to hyperalgesia.49. Ulla fortsatte med att betona att rädsla och undvikande är en central del to improve psychophysiological measures of central sensitization, Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia. deLaplante L. Cognitivebehavioral treatment of insomnia secondary bladder capacity and potassium sensitivity pain site, severity, and character, we performed a secondary analysis of data from the Multiple factors including inflammation, nerve injury, ischemia, peripheral hyperalgesia, metabolic disorders and other resulting in enhanced responsiveness through central sensitization.